During my long run on sunday I developed a small area of pain on the inside aspect of my right leg just lateral to my knee. I was wearing a different pair of shoes and it was 21 miles. I've been icing it, using Ibuprofen cream and continue to notice a dull ache in the area with no swelling. Just wondering if anyone has any input as to what this might be or recommendation to quickly rid of it and still run? I didn't run yesterday but plan to give it a go easy tonight unless it hurts. Thanks for any input as the marathon is coming up quickly!!
Christy H.

thanks for the websites! From reading those it sounds like it might be the medial ligament sprain, maybe just slightly since right now it's a nagging discomfort. I skipped yesterday so going to try slow with kinesiotape and any pain I won't run. Just don't want to take much time off before the marathon, but don't want to injure worse and not be able to run at all. I appreciate your input!
Christy

Have you tried adjusting the cleats a bit to a more natural position for your foot?

Squirrel Queen,
I referred your question to my husband, the Road Bike King.
He says: your knee problems while biking may be more related to the adjustment of your bike than the toe clips.  Make sure the seat height is correct: set it by placing your heel over the axle of the pedal; at full extension of your leg you should have a very little bend in your knee but your hips should not sway.  Step 2: Clip in.  With pedals at 9 and 3 o'clock, drop a plumb line from front of your knee -- should line up with the center of the pedal axle.  If your knee is forward of this line, you are going to get knee pain.  So adjust the saddle forward or back to line up your knee.  Step 3: Clips should be centered in the ball of your foot.  Your foot should be parallel to the crank arm.  
From there, adjust the handlebars for your comfort: do not move the saddle toward the handlebars.
If you are still getting knee pain, you can consider putting shims in your shoes (like orthotics) to support the outside or the inside of your foot.  
You can have a professional bike fitting which, if you intend to ride the bike alot (like training for a tri) is a crucial investment.
My hubby is not a professional, but he spends hours tweaking on his bike and reading the correct adjustment patterns.  He would be happy to talk to you if you like; pm me.
Hope this helps!

Thanks all!  I'll start with turning the cleat and work down the list of suggestions if necessary.
 
It'd be a lot simpler to just run though.